Pembuatan Film Balutan Primer Untuk Luka Bakar yang Mengandung Kolagen Kulit Ikan Gabus (Channa striata)

  • Rahmi Nofita R
  • Elfi Sahlan Ben
  • Yanwirasti Yanwirasti
  • Yufri Aldi

Abstract

Collagen from snakehead fish skin (Channa striata) wound dressing is able to maintain the moisture balance around the wound. Known as modern dressing method, collagen wound dressing is able to accelerate fibrinolysis, fasten angiogenesis, decrease the infection risk, quicken the growth factor creation, and active cell generation. Collagen has an important function in wound healing process because collagen has the ability to hemostatis, interaction with thrombocyte, interaction with fibronectine and increase liquid exudation, improve cellular component, increase growth factor and boost fibroplasia process. Collagen film isolated from snakehead fish (Channa striata) 1%, with additional material such as PVA 4%, propilenglikol 5 %, Gliserin 10% and preservatives nipagin and nipasol. All in all, the collagen characterization result is corresponded to the literature,but it needs improvement for how to dry film, because film contains collagen which can’t be dry at temperatures above 40oC, because it will change the collagen to gelatin.

References

Allen LV, 2002. The Art, Science, and Technology Of Pharmaceutical Compounding, Second Edition, 301, American Pharmaceutical Association: Washington, D.C.

Ansel HC, Allen LV, PopovichNG, 2012. Pharmaceutical Dosage Form And Drug Delivery System. 9th Edition. Lippincott William & Wilkins.

Baker OA, 2006. Polyvynil Alkohol, In: Rowe, RC, Shesky PJ, And Owen SC, (Eds.), Handbook Of Pharmaceutical Excipients, Fifth Edition, 592, Pharmaceutical Press: UK.

Carville K, 2012. Wound Care Manual 6ed Revised & Expanded.Published By Silver Chain, Pharmaceutical Society Of Australia Ltd.

Ditjen POM, 2014. Farmakope Indonesia. Edisi V. Jakarta: Departemen Kesehatan R.I.

Greidane J, Dzene A, Loginova N, Tupureina V, Dzenis M, Savenkova L, 2006. Macromolecular Therapeutic Systems. Sci. Proc. Riga Tech. Univ.: Mat. Sci. Appl. Chem., 12, 61–68.

Harper CA, Petrie EM, 2003. Plastics Material and Process. New Jersey: Johnwiley & Sons, Inc.

Hodgkinson N, Taylor M, 2000. Thermoplastic Poli(Vinyl Alcohol) (Pvoh). Jurnal Of Material World 8: 24-25.

Johnson R, Steer R, 2006. Propilen Glycol, In: Rowe, R. C., Shesky, P. J., And Owen, S. C. (Eds.), Handbook Of Pharmaceutical Excipients, Fifth Edition, 629, Pharmaceutical Press, UK.

Kartika RW, 2015. Perawatan Luka Kronis dengan Modern Dressing CDK-230/ vol. 42: 7, 546-550.

Kibbe AH, 2004. Handbook Of Pharmaceutical Excipients, Third Edition, 442, 572, Pharmaceutical Press, UK.

Kuncari ES, Iskandarsyah, Praptiwi, 2014. Evaluasi, Uji Stabilitas Fisik dan Sineresis Sediaan Gel yang Mengandung Minoksidil, Apigenin dan Perasan Herba Seledri (Apium Graveolens L.) Bul. Penelit. Kesehat, Vol. 42, No. 4: 213-222 221.

Lachman L, Lieberman, Kaning JK, 1994. Teori dan Praktek Farmasi Industri, Edisi 3, Alih Bahasa Oleh S. Suyami, Penerbit Universitas Indonesia: Jakarta.

Martin A, Swarbrick J, Cammarata A, 2008. Farmasi Fisika 2 Edisi Ketiga . Jakarta : UI Press.

Mutia, T, Eriningsih R, 2012. Penggunaan Webs Serat Alginat/Polivinil Alkohol Hasil Proses Elektrospining Untuk Pembalut Luka Primer, J. Riset Industri. 6 (2): 137-147.

Owen SJ, Weller PJ, 2006. Propilen Glycol, In: Rowe, R. C., Shesky, P. J., And Owen, S. C. (Eds.), Handbook Of Pharmaceutical Excipients, Fifth Edition, 624, Pharmaceutical Press, UK.

Price JP, 2006. Glycerin , In: Rowe, R. C., Shesky, P. J., And Owen, S. C. (Eds.), Handbook Of Pharmaceutical Excipients, Fifth Edition, 301, Pharmaceutical Press: UK.

Rowe RC, Sheskey PJ, Quinn ME, 2009. Handbook Of Pharmaceutical Excipients; Usa: Pharmaceutical Press Dan The American Pharmacists Association.

Rodriguez M, Oses J, Ziani K, Mate JI, 2006. Combined Effect Of Plasticizer And Surfactants On The Physical Properties Of Starch Based Edible Films. Journal Of Food Research International. 39:840-846.

Werner S, Grose R, 2003. Regulation Of Wound Healing By Growth Factors And Cytokines. American Physiological Society, 83: 835 – 870.

Whitford D, 2005. Protein Structure And Function. John Wiley & Sons Ltd., England. 528p.
Published
2017-12-27
How to Cite
R, Rahmi Nofita et al. Pembuatan Film Balutan Primer Untuk Luka Bakar yang Mengandung Kolagen Kulit Ikan Gabus (Channa striata). Jurnal Sains dan Teknologi Farmasi, [S.l.], v. 19, n. Supl1, p. s104-s110, dec. 2017. ISSN 2580-5959. Available at: <http://jstf.ffarmasi.unand.ac.id/index.php/jstf/article/view/108>. Date accessed: 18 nov. 2018.