Pengaruh Kombinasi Surfaktan Natrium Lauryl Sulfat dan Benzalkonium Klorida Terhadap Kelarutan Ibuprofen

  • Syofyan Syofyan
  • Tuti Agustia Safari
  • Rieke Azhar

Abstract

A study on the influence of sodium lauryl sulfate and benzalkonium chloride combination on the solubility of ibuprofen has been done. The solubility of ibuprofen with sodium lauryl sulfate, benzalkonium chloride and it’s combination was determined by surface tension method with Du Nouy Tensiometer and by refractive index method with Refractometer ABBE. The solubility was determined at surfactant concentration above the CMC value. Results showed that formula 4 gave the highest solubility of ibuprofen (96,25 %). Combination of the surfactants caused precipitation.

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Published
2017-03-28
How to Cite
SYOFYAN, Syofyan; SAFARI, Tuti Agustia; AZHAR, Rieke. Pengaruh Kombinasi Surfaktan Natrium Lauryl Sulfat dan Benzalkonium Klorida Terhadap Kelarutan Ibuprofen. Jurnal Sains dan Teknologi Farmasi, [S.l.], v. 18, n. 1, p. 69-74, mar. 2017. ISSN 2580-5959. Available at: <http://jstf.ffarmasi.unand.ac.id/index.php/jstf/article/view/19>. Date accessed: 19 july 2018.
Section
Articles