Mikroenkapsulasi Metformin Hidroklorida dengan Penyalut Etilsellulosa Menggunakan Metoda Penguapan Pelarut

  • Deni Noviza
  • Tita Harliana
  • Ade Arinia Rasyad

Abstract

Metformin hydrochloride is a biguanide class of oral antidiabetic drugs that have a half-life 1.5 to 3 hours, and it administration was repeated. In order to support the treatment of diabetic disease, metformin hydrochloride was made into microcapsules as a maintenance dose using solvent evaporation method using ethyl cellulose as a coated. The comparison between metformin hydrochloride and ethyl cellulose were 1: 0.75; 1: 1 and 1: 1.25. Microencapsulation evaluated by microscopic photograph, assay and dissolution test. At the microscopic picture shows metformin hydrochloride veiled by a layer of ethyl cellulose. The amount of metformin hydrochloride in F1 is 20.73%, 15.40% at FII and FIII is 10.11%. The biggest drug release inhibiton was achieved in formula 3 (1; 1.25) with dissolution efficiency was 0.170.

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Published
2017-03-28
How to Cite
NOVIZA, Deni; HARLIANA, Tita; RASYAD, Ade Arinia. Mikroenkapsulasi Metformin Hidroklorida dengan Penyalut Etilsellulosa Menggunakan Metoda Penguapan Pelarut. Jurnal Sains dan Teknologi Farmasi, [S.l.], v. 18, n. 1, p. 75-79, mar. 2017. ISSN 2580-5959. Available at: <http://jstf.ffarmasi.unand.ac.id/index.php/jstf/article/view/20>. Date accessed: 19 july 2018.
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Articles