Uji Bioaktivitas Losartan Terhadap Jaringan Fibrosis Hati Tikus Yang di Induksi Karbon Tetraklorida (CCl4)
Hepatic fibrosis is an inflammation of liver which involves series of cells and mediators. Hepatic fibrosis can lead to cirrhosis. Hepatic fibrosis increase the risk of clinical complication such as portal hypertension and hepatocyte disfunction. This study aimed at finding amarker for non invasive hepatic fibrosis or an antifibrotic by comparison of the degree of hepatic fibrosis after administration of CCl4 and losartan. Thirty five rat’s were divided into 7 groups which were K-1, K-2, K-3, K-4, K-5, K-6, K-7 respectively. K-1 was olive oil control group, K-2, K-3 and K-4 were given CCl4 0,2 ml/100g interperitonially third a week, K-5, K-6 and K-7 were given CCl4 and losartan 5 mg/Kg BB per oral per day. CCl4 and losartan were given for 6 weeks and the change in rat’s hepatic histopathology was observed at week 1st, 4th, and 6th. Histopatology of rat’s liver changed from centrotubular necrosis to centrotubular degeneration but did not show hepatic fibrosis.
Aslam, M, dkk. 2003. Farmasi Klilnik (Clinical Pharmacy). Jakarta : PT.Elex Media Komputindo
Bataller, R., and Brenner, D.A., 2005, Liver fibrosis, The Journal of Clinical Investigation, 115:209-218.
Gressner A.M, Weiskirchen R. 2006. Modern Pathogenetic Concepts of Liver Fibrosis Suggest Stellate Cells and TGF-β as Major Players and Therapeutic Targets. J.Cell.Mol.Med; 10:76-99
Gultom, E.T.M., 2001, Efek Proteksi Kaptopril dan Losartan terhadap Cedera Sel Hati Tikus yang Diinduksi dengan Parasetamol, CCL4, dan Etanol, Iredale, J.P., 2007, Models of Liver Fibrosis: Exploring The Dynamic Nature of Inflammation And Repair In A Solid Organ, J Clin Invest, 117:539-548.
Leija, A., Reyes, J., Rodriquez, L., 2007, Hepatic stellate cells are a major component of liver fibrosis and a target for the treatment of chronic liver disease, Biotecnologia Aplicada, 24:19-25.
Mardini, H., Record, C., Detection Assessment and Monitoring of Hepatic Fibrosis: Biochemistry or Biopsy, Ann Clin Biochemistry, 42:441-47.
Oktavianti, R., Harini, M., Handajani, N.S., 2005, Struktur Histologis Hepar Mencit (Mus musculus L.) setelah
Pemberian Aspartam Secara Oral, Enviro, 5 (1), 30-33.
Reyes, A.G.L., Netzahualcoyotl, A.C., Beiman, G.C., Victor, J.L.D., Gustavo, E., Guajardo, S., Jose, F.I., Vincente, M.O., Luis, A.M.G., Francisco, J.G.G., Guillermo, G., Jorge, E.M.C., 2008, Black Been Extract Ameliorates Liver Fibrosis in Rats with CCl4-Induced Injury, Annals of Hepatology, 7(2):April-June:130-135.
Sebastiani, G., Albert A., 2006. Non Invasive Fibrosis Biomarkers Reduce but Not Substitute The Need for iver Biopsy, Gastroenterol, 12:3682-94.
Susanti, R., Nuryanto, Salasia, S.I.O., 2002, Intoksikasi 2,3,7,8 Tetrachlorodibenzo-p-Dioxin (TCDD):II Efek Terhadap Histopatologis Hati, Ginjal dan Paru Tikus Putih (Rattus novergicus), Biota Vol VII, (1), 29-36