Pengembangan Kulit Buah Kering Asam Kandis sebagai Herbal Medicine: Optimasi Formulasi Tablet Effervesen dan Uji Efeknya Terhadap Kenaikan Berat Badan dan Pola Makan Tikus

  • Henny Lucida
  • Elfi Sahlan Ben
  • Elfi Delita

Abstract

This paper reports an optimization technique of effervescent tablet formulation from the ethanolic extract of “asam kandis” dried rinds (Garcinia cowa Roxb) and an assay of its reconstituted solution effect on rat’s body weight and feeding behavior.


Formulation optimization was done by factorial design of 2 factors (extract concentration; composition of tablet disintegrant) and 3 levels. Nine formulas (FI – FIX) were prepared and subjected to evaluations including granule’s physicochemical and tablet’s pharmaceutical properties. The best formula was then chosen and given orally to 4 groups of rats: that was given standard food, high fat diet, high fat diet with reconstituted tablet 250 mg and high fat diet with reconstituted tablet 500 mg respectively. All groups were given 10 g of standard food every day for 10 days followed by high fat diet for the next 22 days. Two treatment groups were given reconstituted tablet at day 11th. The amount of food consumed by each group was weighed and rat’s body weight was measured.


The optimization technique showed that both factors influenced the physicochemical properties of granules and the pharmaceutical properties of tablets significantly (p < 0.05). FV (extract concentration 500 mg, disintegrant: sodium bicarbonat 500 mg + citric acid 200 mg + tartaric acid 200mg) was chosen as the best. 


Results showed that administration of reconstituted tablet FV to rats increased the bodyweight of the treated groups for the first week which then decreased during the next 3 week observation, while the body weight of control group kept increasing. Reconstituted tablet at dose 500 mg significantly influenced rat’s bodyweight and the feeding behavior (p<0.05). The group given reconstituted tablet 500 mg had the lightest body weight and consumed the least food during 3 weeks observation.

References

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Jena, B.S. ; G.K. Jayaprakasha ; R.P. Singh ; K.K. Sakariah, 2002a, Chemistry and Biochemistry of (-) -hydrocitric acid from Garcinia. J. Agricultural. Food chemistry, 50, 10-22.

Jena, B.S. ; G.K. Jayaprakasha ; Kunnumpurath, 2002b \\ICI-1, Organic Acid from Leaves, Fruit and Rinds of Garcinia cowa. J.Agricultural. Food chemistry, 50(12), 3431-3434.

Lucida, H., F Rozani dan U.O. Putri, (2009), Formulasi Granul Effervesen, Serbuk Instan dan Teh Celup Ekstrak Kulit Buah Kering Garcinia cowa, Roxb. Terstandarisasi, Jurnal Sains dan Teknologi Farmasi, Vol 14, No. 1, hal 43 – 50.

Lucida, H., Armenia dan N.F. Witha (2010), Potensi Garcinia cowa, Roxb. (Asam Kandis) sebagai Bahan Obat Alami Indonesia: Uji Pengaruh Ekstrak Etanol Kulit Buah Kering Asam Kandis terhadap Kadar kolesterol Total Darah Mencit Putih Jantan, Jurnal Farmakologi, Toksikologi dan Bioassay, No. 1, Juli 2010, hal 12 – 18, http://ffarmasi.unand.ac.id/jftb.

Leonhardt, M. and Langhans, W., 2002, Hydroxycitrate Has Long-Term Effects on Feeding Behavior, Body weight Regain and Metabolism after Body Weight Loss in Male Rats, The American Society for Nutritional Sciences,J.Nutr,132.
Published
2017-03-29
How to Cite
LUCIDA, Henny; BEN, Elfi Sahlan; DELITA, Elfi. Pengembangan Kulit Buah Kering Asam Kandis sebagai Herbal Medicine: Optimasi Formulasi Tablet Effervesen dan Uji Efeknya Terhadap Kenaikan Berat Badan dan Pola Makan Tikus. Jurnal Sains dan Teknologi Farmasi, [S.l.], v. 17, n. 2, p. 126-136, mar. 2017. ISSN 2580-5959. Available at: <http://jstf.ffarmasi.unand.ac.id/index.php/jstf/article/view/25>. Date accessed: 19 july 2018.
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Articles